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No specific dose adjustment suggested when tofacitinib coadministered with strong CYP2C19 inhibitors; reduce tofacitinib dose if coadministered with both moderate CYP3A4 and strong CYP2C19 inhibitors .Edgar and Seidel (1997) investigated the consequences of modafinil on sleep-wake EEG and locomotor action in Dwell rats compared with the results of